研究项目：

1.“丁酸及产丁酸菌在维持肠道稳态及重症胰腺炎中的作用研究”，国自然科学基金面上项目，主持，2019.01-2022.12

2.“自身免疫型糖尿病中肠源抗菌肽的功能研究“，江苏省自然科学基金杰出青年项目，2020-2012

3.“针对胰腺健康的酪酸梭菌研究开发”，江苏省双创计划团队项目，2019.01-2021.12

4.“抗菌肽cathelicidins在维持肠道免疫稳态及1型糖尿病发病中的作用研究”，国家自然科学基金重大研究计划（培育项目），主持，2017.01-2019.12

5.“肠道丁酸在1型糖尿病免疫炎症中作用及分子机制研究”,国家自然科学基金面上项目，主持，2016.01-2019.12

6.“短链脂肪酸调控胰肠区域免疫稳态及机理研究”,中央高校专项自主科研项目-重点项目（A类），主持，项目号JUSRP51613A，2016.01-2018.12

7.“功能脂肪酸与抗菌肽的健康机理与药食应用研究”,启动基金，主持，2015.01-2017.12

8.“抗菌肽的天然诱导剂筛选”，国家高端外国专家项目，中方负责人，2014.01-2015.12

9.“抗菌肽cathelicidins对beta细胞功能的免疫调节作用及机理研究”，国家自然科学基金青年项目，主持，2015.01-2017.12

10.“功能活性物质的内源诱导对宿主免疫防御与慢性病防治的影响及相关新型营养产品的开发”，江苏省双创计划人才项目，主持，2015.01-2017.12

11.“新型抗糖尿病胰岛炎症的免疫防御肽内源诱导剂的开发”，江苏省六大人才高峰项目，主持，2015.91-2017.12

12.“膳食脂肪与宿主防御肽在胰腺beta细胞功能和糖尿病预防重的作用与机制研究”，江苏省自然科学基金青年项目，主持，2014.01-2016.12

►代表性文章

1. Sun J, Laetitia Furio, Ramine Mecheri, Anne M. van der Does, Erik Lundeberg, Loredana Saveanu, Yong Chen, Peter van Endert, Birgitta Agerberth, Julien Diana. Pancreatic β-cells express a host defense peptide regulating autoimmune diabetes under the influence of the gut microbiota.Immunity. 2015; 43: 304-317. (IF: 24.1,封面文章)

2. Ren Z, Pan LL, Huang Y, Chen H, Liu Y, Liu H, Tu X, Liu Y, Li B, Dong X, Pan X, Li H, Fu YV, Agerberth B, Diana J,Sun J*. Gut microbiota-CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten-induced enteropathy.EMBO Mol Med. 2021 Jun 14. doi: 10.15252/emmm.202114059. (IF: 12.13,封面文章)

3. Pan LL, Ren Z, Tu X, Liu H, Tay HL, Li J, Pan X, Dong X, Foster PS,Sun J*. GPR109A deficiency promotes IL-33 overproduction and type 2 immune response in food allergy in mice.Allergy. 2021 Apr 8. doi: 10.1111/all.14849.(IF: 13.14)

4. Li J, Pan X, Ren Z, Li B, Liu H, Wu C, Dong X, de Vos P, Pan LL,Sun J*. PRMT2 promotes dextran sulfate sodium-induced colitis by inhibiting SOCS3 via histone H3R8 asymmetric dimethylation.Br J Pharmacol. 2021 Jul. Accepted. (IF: 8.739)

5. Jia LL, Zhang M, Liu H,Sun J*, Pan LL. Early-life fingolimod treatment improves intestinal homeostasis and pancreatic immune tolerance in non-obese diabetic mice.Acta Pharmacol Sin. 2021 Jan 20. doi: 10.1038/s41401-020-00590-4. (IF: 6.15)

6. Pan LL, Li BB, Pan XH,Sun J*. Gut microbiota in pancreatic diseases: possible new therapeutic strategies.Acta Pharmacol Sin. 2021 Jul;42(7):1027-1039. doi: 10.1038/s41401-020-00532-0.(IF: 6.15,封面文章)

7. Dong X, Sun R, Wang J, Yu S, Cui J, Guo Z, Pan X,Sun J*, Yang J, Pan LL. Glutathione S-transferases P1-mediated interleukin-6 in tumor-associated macrophages augments drug-resistance in MCF-7 breast cancer.Biochem Pharmacol. 2020 Dec;182:114289. doi: 10.1016/j.bcp.2020.114289. (IF: 5.852)

8. Pan LL, Ren Z, Liu Y, Zhao Y, Li H, Pan X, Fang X, Liang W, Wang Y, Yang J,Sun J*. A novel danshensu derivative ameliorates experimental colitis by modulating NADPH oxidase 4-dependent NLRP3 inflammasome activation. JCell Mol Med. 2020 Nov;24(22):12955-12969. doi: 10.1111/jcmm.15890. (IF: 5.313)

9. Dong X, Wu D, Zhang Y, Jia L, Pan X,Sun J*, Pan LL. Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway.Antioxidants (Basel). 2020 Jun 5;9(6):491. doi: 10.3390/antiox9060491. (IF: 6.312)

10. Pan LL, Liang W, Ren Z, Li C, Chen Y, Niu W, Fang X, Liu Y, Zhang M, Diana J, Agerberth B,Sun J*. Cathelicidin-related antimicrobial peptide protects against ischaemia reperfusion-induced acute kidney injury in mice.Br J Pharmacol.2020 Jan 24. doi: 10.1111/bph.14998. (IF: 7.7)

11. Zhou Q, Pan LL, Xue R, Ni G, Duan Y, Bai Y, Shi C, Ren Z, Wu C, Li G, Agerberth B, Sluijter JP,Sun J*, Xiao J. The anti-microbial peptide LL-37/CRAMP levels are associated with acute heart failure and can attenuate cardiac dysfunction in multiple preclinical models of heart failure.Theranostics.2020 15;10(14):6167-6181. doi: 10.7150/thno.46225. (IF: 8.6)

12. Pan X, Fang X, Wang F, Li H, Niu W, Liang W, Wu C, Li J, Tu X, Pan LL,Sun J*. Butyrate ameliorates caerulein-induced acute pancreatitis and associated intestinal injury by tissue specific mechanisms.Br J Pharmacol.2019 Jul 26. doi: 10.1111/bph.14806. (IF: 7.7)

13. Bei Y#, Pan LL#, Zhou Q#, Zhao C, Xie Y, Wu C, Meng X, Gu H, Xu J, Zhou L, Sluijter JPG, Das S, Agerberth B,Sun J*, Xiao J*. Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury.BMC Med. 2019. DOI: 10.1186/s12916-019-1268-y. (IF: 9.1)

14. Pan X, Li J, Tu X, Wu C, Liu H, Luo Y, Dong X, Li X, Pan LL,Sun J*. Lysine-specific demethylase-1 regulates fibroblast activation in pulmonary fibrosis via TGF-β1/Smad3 pathway.Pharmacol Res.2020 152:104592. doi: 10.1016/j.phrs.2019.104592. (IF: 5.6)

15. Li J, Pan X, Yang J, Jia L, Wu C, He L, Ren Z, Pan L,Sun J*. Enteral virus depletion modulates experimental acute pancreatitis via toll-like receptor 9 signaling.Biochem Pharmacol.2020;171:113710. (IF: 4.96)

16. Jia L, Cao M, Chen H, Zhang M, Dong X, Ren Z,Sun J*, Pan LL*. Butyrate Ameliorates Antibiotic-Driven Type 1 Diabetes in the Female Offspring of Nonobese Diabetic Mice.J Agric Food Chem.2020 Mar 11;68(10):3112-3120. doi: 10.1021/acs.jafc.9b07701. (IF: 4.2)

17. Jia L, Chen H, Yang J, Fang X, Niu W, Zhang M, Li J, Pan X, Ren Z,Sun J*, Pan LL. Combinatory antibiotic treatment protects against experimental acute pancreatitis by suppressing gut bacterial translocation to pancreas and inhibiting NLRP3 inflammasome pathway.Innate Immun. 2020 Jan;26(1):48-61. doi: 10.1177/1753425919881502. (IF: 2.648)

18. Liu H, Pan LL, Lv S, Yang Q, Zhang H, Chen W, Lv Z,Sun J*. Alterations of Gut Microbiota and Blood Lipidome in Gestational Diabetes Mellitus With Hyperlipidemia.Front Physiol. 2019 Aug 6. doi: 10.3389/fphys.2019.01015. (IF: 4.562)

19. Wu C, Pan LL, Luo Y, Niu W, Fang X, Liang W, Li J, Li H, Pan X, Yang G, Chen W, Zhang H, Lakey JRT, Agerberth B, de Vos P,Sun J*. Low Methoxyl Pectin Protects against Autoimmune Diabetes and Associated Caecal Dysfunction.Mol Nutr Food Res.2019 Aug 18:e1900307. doi: 10.1002/mnfr.201900307. (IF: 5.3)

20. Wu C, Pan LL, Niu W, Fang X, Liang W, Li J, Li H, Pan X, Chen W, Zhang H, Lakey JRT, Agerberth B, de Vos P,Sun J*. Modulation of Gut Microbiota by Low Methoxyl Pectin Attenuates Type 1 Diabetes in Non-obese Diabetic Mice.Front Immunol.2019 Jul 30;10:1733. doi: 10.3389/fimmu.2019.01733. eCollection 2019. (IF: 5.0)

21. Pan LL, Niu W, Fang X, Liang W, Li H, Chen W, Zhang H, Bhatia M,Sun J*. Clostridium butyricum Strains Suppress Experimental Acute Pancreatitis by Maintaining Intestinal Homeostasis.Mol Nutr Food Res.2019 Apr 29:e1801419. doi: 10.1002/mnfr.201801419. (IF: 5.3)

22. Sun J*, de Vos P. Editorial: Immunomodulatory Functions of Nutritional Ingredients in Health and Disease.Front Immunol.2019 Jan 24;10:50. doi: 10.3389/fimmu.2019.00050. eCollection 2019. (IF: 5.0)

23. Ren Z, Li H, Zhang M, Zhao Y, Fang X, Li X, Chen W, Zhang H, Wang Y, Pan LL,Sun J*. A Novel Derivative of the Natural Product Danshensu Suppresses Inflammatory Responses to Alleviate Caerulein-Induced Acute Pancreatitis.Front Immunol. 2018; 9:2513. (IF: 5.0)

24. Pan LL, Deng Y-Y, Wang R, Wu C, Li J, Niu W, Yang Q, Madhav B, Gudmundsson HG, Agerberth B, Diana J andSun J*. Lactose Induces Phenotypic and Functional Changes of Neutrophils and Macrophages to Alleviate Acute Pancreatitis in Mice.Front Immunol. 2018; 9:751. (IF: 5.0)

25. He Y, Wu C, Li J, Li H, Sun Z, Zhang H, de Vos P, Pan LL*,Sun J*. Inulin-Type Fructans Modulates Pancreatic-Gut Innate Immune Responses and Gut Barrier Integrity during Experimental Acute Pancreatitis in a Chain Length-Dependent Manner.Front Immunol. 2017; 8:1209. (IF: 5.0)

26. Jia L, Shan K, Pan LL, Feng N, Lv Z, Sun Y, Li J, Wu C, Zhang H, Chen W, Diana J,Sun J*, Chen YQ*. Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells.Front Immunol.2017; 8:1345. (IF: 5.0)

27. Pan LL, Li J, Shamoon M, Bhatia M,Sun J*. Recent Advances on Nutrition in Treatment of Acute Pancreatitis.Front Immunol.2017; 8:762. (IF: 5.5)

28. Sun J*, Xu M, Diana J, Ortsäter H,‎Flodström-Tullberg M, Haeggström Z. J, Agerberth B. The antimicrobial peptide cathelicidin is a positive regulator of pancreaticβ-cell function.FASEB J.2016;30: 884-894. (IF: 5.6)

29. Muhammad Shamoon, Yongquan Chen, Madhav Bhatia*,Sun J*. Therapeutic implications of innate immune system in acute pancreatitis.Expert Opin Ther Targets.2016; 20: 73-87. (IF: 4.9)

30. Chen K, Chen H, M Faas M, J de haan B, Li J, Xiao P, Zhang H, Diana J, de Vos P,Sun J*. Specific inulin-type fructan fibers protect against autoimmune diabetes by modulating gut immunity, barrier function and microbiota homeostasis.Mol Nutr Food Res2017; 61(8) (IF: 5.2)

31. Sun Y, He Y, Wang F, Zhang H, de Vos P,Sun J*. Low-methoxyl lemon pectin attenuates inflammatory responses and improves intestinal barrier integrity in caerulein-induced experimental acute pancreatitis.Mol Nutr Food Res2017; 61(4) (IF: 5.2)

32. Dong Z, Shang H, Chen YQ, Pan LL, Bhatia M,Sun J*. Sulforaphane protects pancreatic acinar cell injury by modulating Nrf2-mediated oxidative stress and NLRP3 inflammatory pathway.Oxid Med Cell Longev2016; 2016:7864150. (IF: 4.9)

33. Sun J, Dahlén B, Agerberth B, Haeggström ZJ. The host defense peptide LL-37 induces release of eicosanoids and eosinophil cationic protein from human eosinophils – implications for asthma.Allergy.2013;68:304-311. (IF: 6.0)

34. Sun J, Ramnath RD, Tamizhselvi R, Bhatia M. PKC and PI3K-Akt Pathways are Involved in Substance P-Induced ERK1/2-NF-κB Activation and Chemokine Expression in Mouse Macrophages.FASEB J.2009;23:997-1010. (IF: 6.401)

35. Sun J, Ramnath RD, Zhi L, Tamizhselvi R, Bhatia M. Substance P Enhances NF-κB Transactivation and Chemokine Response in Murine Macrophages via ERK1/2 and p38 MAPK Signaling Pathways.Am J Physiol Cell Physiol.2008; 294:C1586-1596. (IF: 4.230)