►个人简介
陈永泉，welcome皇冠地址教授、博士生导师，“国家级引进人才”入选者。
长期致力于功能脂肪酸等活性成分对防治和延缓前列腺癌发生机制的研究，研究兴趣主要集中在脂肪合成、代谢与癌症相关关系及机制。已在国际核心期刊上发表论文120余篇，其中50余篇发表在SCI影响因子5.0以上杂志，总引用次数接近4000，H-index为45。作为会议主席或分会主
席组织或参加国际会议10多次,做大会报告和特邀报告70余次，兼任44种英文杂志编委和审稿人。是NIH (美国国立卫生健康研究院)，DOD (美国国防部)、 “国家级引进人才”入选者，国家自然科学基金等百余个美国及其他国家资助机构的评审专家组成员。自2003年以来,共承担研究课题30余项，研究课题总经费超过4000万美元，其中作为PI的超过2000万美元。申请发明专利30余项，已授权国际专利4项，国内专利17项。
►教育背景
1990/06-1993/02美国Wayne State University放射肿瘤系 博士后
1984/06-1989/09比利时Free University of Brussels肿瘤系 博士学位
1978/06-1982/08复旦大学 生物系 学士学位
►研究方向
功能脂肪酸等活性成分对防治和延缓前列腺癌发生机制的研究，包括脂肪合成、代谢与癌症相关关系及机制。
研究项目：
1. 靶向人体脂质代谢异变以精准诊治恶性前列腺癌的机制与应用研究：江苏省重点研发计划项目. (BE2018624) 2018.07-2021.06
2. 铁死亡中脂质过氧化物的组成及其导致细胞死亡机制的研究：国家自然科学基金面上项目. (31771539) 2018-2021
3. 深海鱼油中长链ω-3 PUFA代谢产物的组成和功能：科技部十三五国家重点研发计划项目（课题2）.（2017YFD0400200）2017.07-2020.12
4. ω3多不饱和脂肪酸代谢产物前列腺素E3(PGE3)和消退素(resolvins)抗前列腺癌机制的研究：国家自然科学基金面上项目.(31471128)2015.01-2018.12
5. 江苏省双创计划：江苏省科技厅. 2012.11-2015.12.
6. 江苏省创新团队：江苏省科技厅. 2012.12-2015.12.
7. Omega-3 PUFA-gene interaction in prostate cancer：NIH. (R01 CA163273) 2012.05-2017.04.
8. Effects of dietary omega-3 fatty acids on Akt signaling in prostate cancer：NIH. (R01 CA107668) 2009.03-2012.02.
9. Mechanism of fish oil supplement in prevention of cancer：NIH. (P01 CA106742) 2006.03-2012.02.
1. Hao D, Chen H, Hao G, Yang B, Zhang B, Zhang H, Chen W, Chen YQ.Production of conjugated linoleic acid by heterologous expression of linoleic acid isomerase in oleaginous fungus Mortierella alpina.Biotechnol Lett. 2015 Jun 25. [Epub ahead of print] PubMed PMID: 26109146.
2. Chen H, Hao G, Wang L, Wang H, Gu Z, Liu L, Zhang H, Chen W, Chen YQ.Identification of a critical determinant that enables efficient fatty acid synthesis in oleaginous fungi.Sci Rep. 2015 Jun 10;5:11247. doi: 10.1038/srep11247. PubMed PMID: 26059272; PubMed Central PMCID: PMC4462047.
3. Mao B, Li D, Zhao J, Liu X, Gu Z, Chen YQ, Zhang H, Chen W.Metagenomic insights into the effects of fructo-oligosaccharides (FOS) on the composition of fecal microbiota in mice.J Agric Food Chem. 2015 Jan 28;63(3):856-63. doi: 10.1021/jf505156h. Epub 2015 Jan 17. PubMed PMID: 25598242.
4. Yang B, Chen H, Stanton C, Ross RP, Zhang H, et al. Review of the roles of conjugated linoleic acid in health and disease. Journal of functional foods. 2015; 15:314-325.
5. Tang X, Chen H, Chen YQ, Chen W, Garre V, Song Y, Ratledge C.Comparison of Biochemical Activities between High and Low Lipid-Producing Strains of Mucor circinelloides: An Explanation for the High Oleaginicity of Strain WJ11.PLoS One. 2015 Jun 5;10(6):e0128396. doi: 10.1371/journal.pone.0128396. eCollection 2015. PubMed PMID: 26046932; PubMed Central PMCID: PMC4457416.
6. Xing J, Wang G, Zhang Q, Liu X, Gu Z, Zhang H, Chen YQ, Chen W.Determining antioxidant activities of lactobacilli cell-free supernatants by cellular antioxidant assay: a comparison with traditional methods.PLoS One. 2015 Mar 19;10(3):e0119058. doi: 10.1371/journal.pone.0119058. eCollection 2015. PubMed PMID: 25789875; PubMed Central PMCID: PMC4366247.
7. Gu Z, Shan K, Chen H, Chen YQ. n-3 Polyunsaturated Fatty Acids and Their Role in Cancer Chemoprevention. Current pharmacology reports. 2015. DOI 10.1007/s40495-015-0043-9
8. Zhang H, Zhang L, Chen H, Chen YQ, Chen W, Song Y, Ratledge C.Enhanced lipid accumulation in the yeast Yarrowia lipolytica by over-expression of ATP:citrate lyase from Mus musculus.J Biotechnol. 2014 Dec 20;192 Pt A:78-84. PubMed PMID: 25450640.
9. Tang X, Zhang H, Chen H, Chen YQ, Chen W, Song Y.Effects of 20 standard amino acids on the growth, total fatty acids production, and γ-linolenic acid yield in Mucor circinelloides.Curr Microbiol. 2014 Dec;69(6):899-908. doi: 10.1007/s00284-014-0671-z. Epub 2014 Aug 13. PubMed PMID: 25117649.
10. Mao B, Li D, Zhao J, Liu X, Gu Z, Chen YQ, Zhang H, Chen W.In vitro fermentation of lactulose by human gut bacteria.J Agric Food Chem. 2014 Nov 12;62(45):10970-7. doi: 10.1021/jf503484d. Epub 2014 Nov 3. PubMed PMID: 25340538.
11. Hao G, Chen H, Du K, Huang X, Song Y, Gu Z, Wang L, Zhang H, Chen W, Chen YQ.Increased fatty acid unsaturation and production of arachidonic acid by homologous over-expression of the mitochondrial malic enzyme in Mortierella alpina.Biotechnol Lett. 2014 Sep;36(9):1827-34. doi: 10.1007/s10529-014-1546-x. Epub 2014 May 27. PubMed PMID: 24863290; PubMed Central PMCID: PMC4386067.
12. Yang J, Hu X, Zhang H, Chen H, Kargbo MR, Zhao J, Song Y, Chen YQ, Zhang H, Chen W.Expression, purification, and characterization of NADP+-dependent malic enzyme from the oleaginous fungus Mortierella alpina.Appl Biochem Biotechnol. 2014 Aug;173(7):1849-57. doi: 10.1007/s12010-014-0971-6. Epub 2014 May 27. PubMed PMID: 24861319.
13. Yang B, Chen H, Gu Z, Tian F, Ross RP, Stanton C, Chen YQ, Chen W, Zhang H.Synthesis of conjugated linoleic acid by the linoleate isomerase complex in food-derived lactobacilli.J Appl Microbiol. 2014 Aug;117(2):430-9. doi: 10.1111/jam.12524. Epub 2014 May 14. PubMed PMID: 24750362; PubMed Central PMCID: PMC4306591.
14. Zhai Q, Wang G, Zhao J, Liu X, Narbad A, Chen YQ, Zhang H, Tian F, Chen W.Protective effects of Lactobacillus plantarum CCFM8610 against chronic cadmium toxicity in mice indicate routes of protection besides intestinal sequestration.Appl Environ Microbiol. 2014 Jul;80(13):4063-71. doi: 10.1128/AEM.00762-14. Epub 2014 Apr 25. PubMed PMID: 24771031; PubMed Central PMCID: PMC4054212.
15. Liu Y, He Y, Jin A, Tikunov AP, Zhou L, Tollini LA, Leslie P, Kim TH, Li LO, Coleman RA, Gu Z, Chen YQ, Macdonald JM, Graves LM, Zhang Y.Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation.Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):E2414-22. doi: 10.1073/pnas.1315605111. Epub 2014 May 28. PubMed PMID: 24872453; PubMed Central PMCID: PMC4060669.
16. Suburu J, Shi L, Wu J, Wang S, Samuel M, Thomas MJ, Kock ND, Yang G, Kridel S, Chen YQ.Fatty acid synthase is required for mammary gland development and milk production during lactation.Am J Physiol Endocrinol Metab. 2014 May 15;306(10):E1132-43. doi: 10.1152/ajpendo.00514.2013. Epub 2014 Mar 25. PubMed PMID: 24668799; PubMed Central PMCID: PMC4116404.
17. Hao G, Chen H, Wang L, Gu Z, Song Y, Zhang H, Chen W, Chen YQ.Role of malic enzyme during fatty acid synthesis in the oleaginous fungus Mortierella alpina.Appl Environ Microbiol. 2014 May;80(9):2672-8. doi: 10.1128/AEM.00140-14. Epub 2014 Feb 14. PubMed PMID: 24532075; PubMed Central PMCID: PMC3993310.
18. Suburu J, Lim K, Calviello G, Chen YQ.RE: Serum phospholipid fatty acids and prostate cancer risk in the SELECT trial.J Natl Cancer Inst. 2014 Apr;106(4):dju023. doi: 10.1093/jnci/dju023. Epub 2014 Mar 31. PubMed PMID: 24685923; PubMed Central PMCID: PMC4318937.
19. Zhao S, Zhang Q, Liu X, Hao G, Zhao J, et al. The protective role of glycine betaine in Lactobacillus plantarum ST-III against salt stress. Food control. 2014; 44:208-213.
20. Chen P, Zhang Q, Dang H, Liu X, Tian F, et al. Screening for potential new probiotic based on probiotic properties and alpha-glucosidase inhibitory activity. Food control. 2014; 35:65-72.
